Piroxicam

Piroxicam is a long-acting non-steroidal anti-inflammatory drug (NSAID) belonging to the oxicam group, commonly prescribed for chronic inflammatory conditions such as osteoarthritis and rheumatoid arthritis. Its extended half-life allows once-daily dosing in many patients, making it a convenient option for long-term management of persistent joint pain and stiffness.

The drug exerts its therapeutic effect by inhibiting cyclooxygenase enzymes involved in prostaglandin synthesis. By reducing these inflammatory mediators, piroxicam helps decrease joint swelling, improve range of motion, and relieve pain associated with chronic musculoskeletal disorders. Because of its sustained action, it is particularly useful in patients requiring continuous anti-inflammatory coverage throughout the day.

In orthopedic practice, piroxicam is typically reserved for patients who need longer-duration NSAID therapy and who tolerate the drug well. It is generally recommended to take the medication with food to reduce gastrointestinal irritation. Careful patient selection is important, especially in older adults and those with a history of gastric ulcer, kidney disease, or cardiovascular risk.

Like other NSAIDs, prolonged use of piroxicam may increase the risk of gastric irritation, fluid retention, and renal effects in susceptible individuals. Regular medical follow-up helps ensure safe and effective therapy. When prescribed appropriately and monitored carefully, piroxicam remains a useful option for managing chronic inflammatory joint conditions.